S-4 Pharmaceutical Organic Chemistry III - Free Notes

Pharmaceutical Organic Chemistry III Notes (S-4)

Pharmaceutical Organic Chemistry III Notes

Below are well-organized, unit-wise POC III notes available for free.
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Unit 1

Stereo isomerism

Unit 1 Covers stereoisomerism focusing on optical isomerism, optical activity, enantiomers, diastereomers, meso compounds, chirality, and symmetry. Includes DL and RS nomenclature, sequence rules, reactions of chiral molecules, racemic modification, resolution, and asymmetric synthesis.

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Unit 2

Geometrical isomerism

Unit 2 Covers geometrical isomerism with Cis-Trans, E/Z, and Syn-Anti nomenclature. Discusses methods to determine configuration, conformational isomerism in ethane, n-butane, cyclohexane, atropisomerism in biphenyls, and conditions for optical activity. Includes stereospecific and stereoselective reactions.

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Unit 3

Heterocyclic compounds

It covers nomenclature, classification, synthesis, reactions, and medicinal uses of heterocyclic compounds like pyrrole, furan, and thiophene. Discusses their relative aromaticity and reactivity, highlighting structural features and chemical behavior important in medicinal chemistry.

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Unit 4

Heterocycles: Synthesis, Reactions & Uses

Focuses on synthesis, reactions, and medicinal uses of heterocyclic compounds: pyrazole, imidazole, oxazole, thiazole, pyridine, quinoline, isoquinoline, acridine, and indole. Discusses the basicity of pyridine. Also includes synthesis and medicinal importance of pyrimidine, purine, azepines, and their derivatives.

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Unit 5

Reactions of synthetic importance

Unit 5 Covers synthetically important reactions including metal hydride reductions like NaBH₄, Wolff-Kishner reduction, Oppenauer oxidation, and Dakin reaction. Also includes Beckmann and Schmidt rearrangements, and Claisen-Schmidt condensation.

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