Stereoisomerism U-1 Notes

Buy Premium

Get The High-Quality Pdf Notes on App

Stereoisomerism

  • Stereoisomerism
  • Optical Isomerism
  • Enantiomers
  • Diastereomerism
  • Meso Compounds
  • Elements of Symmetry
  • Chiral and Achiral Molecules
  • Presentation of Molecules
  • D-L System of Nomenclature (Fischer Nomenclature)
  • Sequence Rules (Cahn–Ingold–Prelog Rules)
  • R-S System of Nomenclature (Absolute Configuration)
  • Distribution Law
  • Reactions of Chiral Molecules
  • Racemic Modification (Racemization)
  • Resolution of Racemic Mixture
  • Asymmetric Synthesis (Chiral Synthesis)

Other Units of Pharmaceutical Organic Chemistry III

Unit 2
Unit 3
Unit 4
Unit 5
Pharmaceutical Organic Chemistry III

Other Subjects of B Pharmacy 4th Semester

Topic wise notes of:

Medicinal Chemistry I

Select

Topic wise notes of:

Physical Pharmaceutics II

  • Colloidal dispersions
  • Rheology & Deformation of solids
  • Coarse dispersion
  • Micromeretics
  • Drug stability
Select

Topic wise notes of:

Pharmacology I

  • Introduction to Pharmacology & Pharmacokinetics
  • Pharmacodynamics & Drug Interaction
  • Pharmacology of drugs acting on peripheral nervous system
  • Pharmacology of drugs acting on central nervous system-1
  • Pharmacology of drugs acting on central nervous system-2
Select

Topic wise notes of:

Pharmacognosy & Phytochemistry I

  • Pharmacognosy: Sources, Classification, and Quality Control
  • Cultivation and Conservation of Medicinal Plants
  • Plant tissue culture
  • Role of Pharmacognosy and Secondary Metabolites
  • Drugs of Natural Origin: Plant, Marine, and Primary Metabolites
Select

Summary of Unit I: Stereoisomerism

Unit I focuses on the fundamental concepts of stereoisomerism, particularly optical isomerism. It begins with the principles of optical activity, detailing how certain compounds can rotate plane-polarized light, and introduces important types of stereoisomers such as enantiomers, diastereoisomers, and meso compounds. The concept of chirality is thoroughly discussed, including the distinction between chiral and achiral molecules, along with the role of elements of symmetry in determining molecular chirality.

The unit also covers nomenclature systems used to describe optical isomers. This includes the DL system, which classifies compounds based on their relationship to glyceraldehyde, and the RS system, which uses the Cahn-Ingold-Prelog sequence rules to assign absolute configuration to chiral centers.

Further, the unit explores the chemical behavior of chiral molecules, focusing on their reactions and how chirality affects reactivity and product formation. The concept of racemic mixtures—equimolar mixtures of enantiomers—is introduced, along with methods for racemic modification and resolution, which are techniques used to separate racemic mixtures into individual enantiomers.

Finally, the unit discusses asymmetric synthesis, a crucial strategy in organic synthesis aimed at selectively producing one enantiomer over another. Both partial and absolute asymmetric synthesis are included, highlighting their importance in pharmaceutical chemistry for the development of optically pure drugs with desired biological activity.

This unit provides a comprehensive understanding of stereochemistry, vital for advanced studies in medicinal and pharmaceutical chemistry.

At FirstHope, we provide BPharm notes that are topic-wise, easy to understand, and designed strictly as per the AKTU and Other Universities, hence designed according to PCI syllabus.

Thank you for reading from Firsthope's notes, don't forget to check YouTube videos!